Elucidating the principles of biological systems and diversification through epigenomics
It is estimated that more than ten million species exist on Earth. While each organism faithfully inherits its genetic information (genome), it has also diversified and evolved over time. Our laboratory focuses on the epigenome, which plays a key role in both the inheritance and diversification of genetic information. We aim to understand how epigenomic information—such as modifications of DNA, RNA, and histone proteins—regulates gene expression and contributes to biological processes and their diversity. To achieve this, we employ a multidisciplinary approach combining molecular genetics, biochemistry, genomics, and computational biology.
We primarily use plants as our model system. Plants possess a remarkable ability to adapt flexibly to environmental changes, and this adaptability is thought to be supported by dynamic gene regulation mediated by the epigenome. Using genetic approaches, we identify epigenomic modifications such as histone modifications and DNA methylation, as well as their regulatory factors. In addition, we aim to achieve a comprehensive understanding of epigenomic regulatory networks. Furthermore, we investigate how plants utilize epigenomic information to memorize environmental inputs, respond to them, and control development and physiology in an adaptive manner.
News
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Update
The laboratory has moved to the Division of Biological Science, Graduate School of Science, Kyoto University.
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Update
Our laboratory website has been launched. The illustration on the homepage was created by Koizumi.
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Paper
A paper by Hoshino has been published in Genes to Cells.
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Paper
A paper by Oya has been published in Plant Communications.
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Paper
A paper by Noyori and Mori has been published in Nature Communications.
We Are Recruiting New Members
The Inagaki Laboratory is currently recruiting students for both Master’s and Doctoral programs. We welcome motivated students who are eager to engage in plant epigenomics research and contribute to the creation of new knowledge. We also encourage applications from postdoctoral researchers who are interested in actively contributing to and shaping our research environment. With the rapid advancement of cutting-edge technologies, epigenomics research continues to expand into new frontiers. We are looking forward to welcoming those who are excited to explore and enjoy the process of discovery together. We are happy to discuss research topics, lab placement, and arrange lab visits at any time, so please feel free to contact us if you are interested.